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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Thromboxane A2 receptor
Species	Rattus norvegicus (Rat)
Gene	Tbxa2r
Synonym	prostanoid TP receptor TP receptor TXA2-R TXR2
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MWLNSTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAVVASQHAALLDWRATDPGCRLCHFMGAAMVFFGLCPLLLGAAMAAERFVGITRPFSRPAATSRRAWATVGLVWVGAGTLGLLPLLGLGRYSVQYPGSWCFLTLGAERGDVAFGLMFALLGSVSVGLSLLLNTVSVATLCRVYHAREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFILQTLLQTLPVMSPSGQLLRTTERQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFTSQLQAVSLHSPPTQAMLSGP
UniProt	P34978
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3156
IUPHAR	346
DrugBank	N/A

Ligand

Name	CHEMBL320235
Molecular formula	C26H26FN3O4S
IUPAC name	3-[1-[2-[(4-fluorophenyl)sulfonylamino]ethyl]-2-methyl-3-(pyridin-3-ylmethyl)indol-5-yl]propanoic acid
Molecular weight	495.569
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	3.7
Synonyms	3-{1-[2-(4-Fluoro-benzenesulfonylamino)-ethyl]-2-methyl-3-pyridin-3-ylmethyl-1H-indol-5-yl}-propionic acid BDBM50060381 UK-102333
Inchi Key	LCXZYHVMTALTGH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H26FN3O4S/c1-18-23(16-20-3-2-12-28-17-20)24-15-19(5-11-26(31)32)4-10-25(24)30(18)14-13-29-35(33,34)22-8-6-21(27)7-9-22/h2-4,6-10,12,15,17,29H,5,11,13-14,16H2,1H3,(H,31,32)
PubChem CID	10323516
ChEMBL	CHEMBL320235
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	0.6918 nM	Bioorg. Med. Chem. Lett., (1995) 5:24:3017	ChEMBL
pA2	9.16 nM	PMID9341919	ChEMBL

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