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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
Trace amine receptor 12
Trace amine receptor 7b
TaR-7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3701964
Molecular formulaC17H18N2O3
IUPAC nameN-[4-[(2S)-morpholin-2-yl]phenyl]-1,3-benzodioxol-5-amine
Molecular weight298.342
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.3
SynonymsSCHEMBL12609845
BDBM129423
US8802673, 65
Inchi KeyLFWYZARXTBIWQA-QGZVFWFLSA-N
Inchi IDInChI=1S/C17H18N2O3/c1-3-13(4-2-12(1)17-10-18-7-8-20-17)19-14-5-6-15-16(9-14)22-11-21-15/h1-6,9,17-19H,7-8,10-11H2/t17-/m1/s1
PubChem CID68325602
ChEMBLCHEMBL3701964
IUPHARN/A
BindingDB129423
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki629.1 nM, NoneBindingDB,ChEMBL

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