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GPCR

NameD(1A) dopamine receptor
SpeciesMus musculus (Mouse)
GeneDrd1
SynonymD1 receptor
D1A
DADR
Dopamine D1 receptor
Dopamine-1A receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length446
Amino acid sequenceMAPNTSTMDETGLPVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDAEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPVECSQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVMFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKREEAGGIPKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProtQ61616
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3071
IUPHARN/A
DrugBankN/A

Ligand

NameSKF-75670
Molecular formulaC17H19NO2
IUPAC name3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol
Molecular weight269.344
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP3.0
Synonyms2,3,4,5-Tetrahydro-3-methyl-1-phenyl-1H-3-benzazepine-7,8-diol
3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol
3-Methyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrochloride
3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol
AC1L5AM7
[ Show all ]
Inchi KeyLIHCKGZEDBNUJG-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H19NO2/c1-18-8-7-13-9-16(19)17(20)10-14(13)15(11-18)12-5-3-2-4-6-12/h2-6,9-10,15,19-20H,7-8,11H2,1H3
PubChem CID173871
ChEMBLCHEMBL1193571
IUPHAR936
BindingDB81986
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki1.9 nMPMID2895008BindingDB

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