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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	CHEMBL391429
Molecular formula	C22H29N7O4S
IUPAC name	2-amino-N-[(1S)-1-[2-[[4-(methanesulfonamido)phenyl]methyl]tetrazol-5-yl]-2-phenylmethoxyethyl]-2-methylpropanamide
Molecular weight	487.579
Hydrogen bond acceptor	9
Hydrogen bond donor	3
XlogP	0.9
Synonyms	(S)-N-(1-(2-(4-(methylsulfonamido)benzyl)-2H-tetrazol-5-yl)-2-(benzyloxy)ethyl)-2-amino-2-methylpropanamide BDBM50222163
Inchi Key	BAMBKAQVHMOZTO-LJQANCHMSA-N
Inchi ID	InChI=1S/C22H29N7O4S/c1-22(2,23)21(30)24-19(15-33-14-17-7-5-4-6-8-17)20-25-28-29(26-20)13-16-9-11-18(12-10-16)27-34(3,31)32/h4-12,19,27H,13-15,23H2,1-3H3,(H,24,30)/t19-/m1/s1
PubChem CID	9848305
ChEMBL	CHEMBL391429
IUPHAR	N/A
BindingDB	50222163
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	986.0 nM	PMID17869100	BindingDB,ChEMBL
Ki	<5000.0 nM	PMID17869100	BindingDB,ChEMBL

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