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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	C-C chemokine receptor type 3
Species	Homo sapiens (Human)
Gene	CCR3
Synonym	MIP-1alphaRL-2 (mouse) Eosinophil eotaxin receptor CKR3 chemokine (C-C motif) receptor 3 CD193 CCR3 CCR-3 CC-CKR-3 CC CKR3 C-C CKR-3 [ Show all ]
Disease	Allergic asthma Allergic rhinitis Asthma
Length	355
Amino acid sequence	MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
UniProt	P51677
Protein Data Bank	N/A
GPCR-HGmod model	P51677
3D structure model	This predicted structure model is from GPCR-EXP P51677.
BioLiP	N/A
Therapeutic Target Database	T02752, T85228
ChEMBL	CHEMBL3473
IUPHAR	60
DrugBank	N/A

Ligand

Name	CHEMBL193656
Molecular formula	C28H36N4
IUPAC name	N,N-dimethyl-4-[2-[[2-phenyl-2-(4-phenylpiperazin-1-yl)ethyl]amino]ethyl]aniline
Molecular weight	428.624
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.0
Synonyms	Dimethyl-(4-{2-[2-phenyl-2-(4-phenyl-piperazin-1-yl)-ethylamino]-ethyl}-phenyl)-amine SCHEMBL18840901 BDBM50162396
Inchi Key	BAQQNRHJCRAASN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H36N4/c1-30(2)26-15-13-24(14-16-26)17-18-29-23-28(25-9-5-3-6-10-25)32-21-19-31(20-22-32)27-11-7-4-8-12-27/h3-16,28-29H,17-23H2,1-2H3
PubChem CID	44401188
ChEMBL	CHEMBL193656
IUPHAR	N/A
BindingDB	50162396
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1770.0 nM	PMID15743194	BindingDB,ChEMBL

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