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GPCR

NameGrowth hormone-releasing hormone receptor
SpeciesRattus norvegicus (Rat)
GeneGhrhr
SynonymGhrfr
GHRH receptor
GRF receptor
GRFR
Growth hormone-releasing factor receptor
DiseaseN/A for non-human GPCRs
Length464
Amino acid sequenceMDSLLWATWVLCLLNLWGVALGHLHLECDFITQLRDDELACLQAAEGTNNSSMGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDPGAVKRDCTITGWSDPFPPYPVACPVPLELLTEEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAVFQGDSTDHCSMSTILCKVSVAVSHFATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTACWDLDDSSPYWWIIKGPIVLSVGVNFGLFLNIICILLRKLGPAQGGLHTRAQYCNYLLPWSCPLPQVPRERTDLGPSSHEITVQESGTRNCQLPWRLSKSTLLLIPLFGIHYIIFNFLPDSAGLGIRLPLELGLGSFQGFVVAVLYCFLNQEVRTEISRKWYGHDPELLPARRTCTEWTTPPRSRVKVLTSEC
UniProtQ02644
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3709
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1791208
Molecular formulaC151H247N45O43S
IUPAC name(3S)-3-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2R,5S,8S,17R)-17-[[(2R)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-(carboxymethyl)-5-methyl-3,6,14,18-tetraoxo-1,4,7,13-tetrazacyclooctadecane-8-carbonyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-4-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
Molecular weight3412.97
Hydrogen bond acceptor50
Hydrogen bond donor50
XlogP-14.9
SynonymsN/A
Inchi KeyLMQHLJQEGGEMOG-PSBSXYBFSA-N
Inchi IDInChI=1S/C151H247N45O43S/c1-17-79(12)119(147(238)181-98(52-59-240-16)133(224)191-109(72-198)144(235)173-89(121(158)212)35-27-56-166-149(159)160)195-142(233)107(69-117(210)211)188-131(222)96(47-50-112(156)204)180-136(227)100(61-75(4)5)184-137(228)101(62-76(6)7)182-129(220)91(32-21-24-53-152)177-126(217)93(36-28-57-167-150(161)162)175-123(214)81(14)171-143(234)108(71-197)192-138(229)102(63-77(8)9)183-130(221)95(46-49-111(155)203)172-115(207)70-169-125(216)99(60-74(2)3)189-146(237)118(78(10)11)194-134(225)92(33-22-25-54-153)178-127(218)94(37-29-58-168-151(163)164)179-139(230)103(66-85-40-44-87(202)45-41-85)186-145(236)110(73-199)193-140(231)105(67-113(157)205)190-148(239)120(82(15)200)196-141(232)104(65-83-30-19-18-20-31-83)185-128(219)90-34-23-26-55-165-114(206)51-48-97(176-124(215)88(154)64-84-38-42-86(201)43-39-84)132(223)187-106(68-116(208)209)135(226)170-80(13)122(213)174-90/h18-20,30-31,38-45,74-82,88-110,118-120,197-202H,17,21-29,32-37,46-73,152-154H2,1-16H3,(H2,155,203)(H2,156,204)(H2,157,205)(H2,158,212)(H,165,206)(H,169,216)(H,170,226)(H,171,234)(H,172,207)(H,173,235)(H,174,213)(H,175,214)(H,176,215)(H,177,217)(H,178,218)(H,179,230)(H,180,227)(H,181,238)(H,182,220)(H,183,221)(H,184,228)(H,185,219)(H,186,236)(H,187,223)(H,188,222)(H,189,237)(H,190,239)(H,191,224)(H,192,229)(H,193,231)(H,194,225)(H,195,233)(H,196,232)(H,208,209)(H,210,211)(H4,159,160,166)(H4,161,162,167)(H4,163,164,168)/t79-,80-,81-,82+,88+,89-,90-,91-,92-,93-,94-,95-,96-,97+,98-,99-,100-,101-,102-,103-,104-,105-,106+,107-,108-,109-,110-,118-,119-,120-/m0/s1
PubChem CID56664721
ChEMBLCHEMBL1791208
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Relative potency0.004 -PMID9513600ChEMBL

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