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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Rattus norvegicus (Rat)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProt	P14842
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL322
IUPHAR	6
DrugBank	N/A

Ligand

Name	haloperidol
Molecular formula	C21H23ClFNO2
IUPAC name	4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Molecular weight	375.868
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.2
Synonyms	4763-EP2272537A2 cMAP_000037 4763-EP2295412A1 Dozic (TN) 4763-EP2311801A1 Einalon S FT-0697842 AC-19691 Haldol Aloperidin (TN) API0002885 177716-59-5 BPBio1_000144 4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone BSPBio_000130 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)butan-1-one CAS-52-86-8 KBio2_006477 Poly[2-methoxy-5-(3,7-dimethyoctyoxyl)-1,4-phenylenevinylene] Keselan QTL1_000042 Lopac-H-1512 MFCD00051423 Haloperidol (Haldol) NCGC00015500-02 Haloperidol lactate Serenelfi NCGC00015500-10 Haloperidol, United States Pharmacopeia (USP) Reference Standard SPECTRUM1500325 NCGC00015500-19 HMS1920D03 SR-01000003076-2 NCGC00023875-09 HMS3712G12 Tox21_300475 NSC-615296 InChI=1/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 W-105791 Peluces 4763-EP2275420A1 D0D1AL 4763-EP2298731A1 DSSTox_GSID_34150 4763-EP2311837A1 EU-0100583 AB00052008-21 gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorbutyrophenone AC250 Haldol Solutab Aloperidolo [DCIT] .gamma.-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone BG0211 4'-Fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone BRD-K67783091-001-05-5 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) Butyrophenone, 4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4'-fluoro- 4-[4-(4-chlorophenyl)-4-hydroxypiperidyl]-1-(4-fluorophenyl)butan-1-one CCG-39111 ZINC537822 Pernox KBio3_002869 Prestwick2_000115 Lealgin compositum Resin epoxy LS-48311 Halojust MLS001146904 Haloperidol (JP17/USP/INN) SCHEMBL8264 NCGC00015500-05 Haloperidol [USAN:USP:INN:BAN:JAN] Sigaperidol NCGC00015500-13 Halopidol Spectrum4_000570 NCGC00023875-04 HMS2095G12 STL417208 NINDS_000654 HY-14538 Ulcolind NSC615296 KBio1_000654 4763-EP2292614A1 DivK1c_000654 4763-EP2308867A2 Duraperidol 52-86-8 Fortunan AB00052008_24 GTPL86 Aldo AN-41634 1-Butanone, 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)- Bioperidolo 4-(4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone Brotopon 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone C01814 4763-EP2269989A1 KBio2_003909 Picroside-III KBioSS_001341 Probes1_000255 LNEPOXFFQSENCJ-UHFFFAOYSA- MCULE-3693790133 Haloperido N1910 Haloperidol for system suitability, European Pharmacopoeia (EP) Reference Standard Serenase NCGC00015500-08 Haloperidol, Pharmaceutical Secondary Standard; Certified Reference Material SPBio_001236 NCGC00015500-16 Halosten (TN) SR-01000003076 NCGC00023875-07 HMS3370H11 Tox21_110162 NSC 615296 IDI1_000654 Vesalium Oprea1_509923 4763-EP2272972A1 CS-1971 4763-EP2295413A1 Dozix 4763-EP2311803A1 Einalon S (TN) A0H334 Galoperidol AC1L1G7K Haldol (TN) Aloperidol Apo-Haloperidol BPBio1_001231 4-(4-(para-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone BSPBio_002096 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one CC-16450 KBio2_007526 Prestwick0_000115 Keselan (TN) R 1625 Lopac0_000583 Mixidol Haloperidol (JP15/USP) SC 170973 NCGC00015500-03 Haloperidol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material Sernas NCGC00015500-11 Haloperidolum Spectrum2_001268 NCGC00016234-01 HMS2089M15 SR-01000003076-8 NCGC00254503-01 HMS502A16 Tox21_500583 NSC-757054 J6292F8L3D W0039 Peluces (TN) CCRIS 1630 4763-EP2277872A1 4763-EP2298776A1 DSSTox_RID_79117 4763-EP2316834A1 Eukystol AB00052008-22 gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorobutyrophenone ACM1189986591 Halidol Aloperidolo [Italian] .gamma.-[4-(p-Chlorphenyl)-4-hydroxpiperidino]-p-fluorbutyrophenone BIDD:GT0128 4'-Fluoro-4-(4-hydroxy-4-p-chlorophenylpiperidino)butyrophenone BRD-K67783091-003-03-6 4-[4-(4-Chlorophenyl)-4-hydroxy- 1-piperidinyl]-1-(4-fluorophenyl)- 1-butanone Butyrophenone, 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4'-fluoro- 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone Pharmakon1600-01500325 KBioGR_000980 Prestwick3_000115 Linton S1920 McM-JR-1625 Halol MolPort-000-883-311 Haloperidol 1.0 mg/ml in Methanol Serenace NCGC00015500-06 Haloperidol, 1 Sigaperidol (TN) NCGC00015500-14 Halopoidol Spectrum5_000788 NCGC00023875-05 HMS2234P08 SW196557-4 Novo-Peridol I14-13404 Uliolind NSC757054 KBio2_001341 CHEMBL54 4763-EP2295061A1 Dozic 4763-EP2308870A2 Duraperidol (TN) 61788-97-4 FT-0669100 AB2000375 H 1512 Aloperidin AOB5645 1-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)- Bioperidolo (TN) 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one Brotopon (TN) 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one C21H23ClFNO2 4763-EP2269990A1 KBio2_004958 Pms Haloperidol KBioSS_002395 Probes2_000296 LNEPOXFFQSENCJ-UHFFFAOYSA-N MDMO-PPV NCGC00015500-01 Haloperidol Intensol Serenase (TN) NCGC00015500-09 Haloperidol, powder SPBio_002069 NCGC00015500-17 HMS1568G12 SR-01000003076-11 NCGC00023875-08 HMS3657I13 Tox21_110162_1 NSC-170973 IN1474 VU0239704-10 Pekuces 4763-EP2272973A1 D00136 4763-EP2295439A1 DSSTox_CID_14150 4763-EP2311824A1 EINECS 200-155-6 AB00052008 gamma-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone AC1Q77Z0 Haldol La Aloperidolo BDBM21398 4'-Fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone BRD-K67783091-001-04-8 4-(4-Hydroxy-4'-chloro-4-phenylpiperidino)-4'-fluorobutyrophenone Butyrophenone, 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidino)- 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone CCG-36042 Peridol KBio3_001316 Prestwick1_000115 L000288 R-1625 LP00583 MLS000028450 Haloperidol (JP15/USP/INN) SC-81035 NCGC00015500-04 Haloperidol [USAN:INN:BAN:JAN] Sernel NCGC00015500-12 Haloperidolum [INN-Latin] Spectrum3_000448 NCGC00023875-02 HMS2091J09 ST50319916 NCGC00261268-01 HSDB 3093 TR-018722 NSC170973 KB-79571 WLN: T6NTJ A3VR DF& DQ DR DG CHEBI:5613 4763-EP2277876A1 DB00502 4763-EP2305260A1 DTXSID4034150 5-21-02-00377 (Beilstein Handbook Reference) Eukystol (TN) AB00052008_23 gamma-[4-(p-chlorophenyl)-4-hydroxypiperidino]-p-fluorobutyrophenone AKOS000280660 Aloperidon 1-(3-p-Fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine Biomol-NT_000035 4'-Fluoro-4-[4-hydroxy-4-(4'-chlorophenyl)piperidino]butyrophenone BRN 0331267 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl) -1-butanone C-35402 4-[4-(para-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone Phenolic epoxy resin KBioGR_002390 Prestwick_250 Linton (TN) SBI-0050565.P004 McN-JR-1625 Halopal MRF-0000027 Haloperidol for peak identification, European Pharmacopoeia (EP) Reference Standard Serenace (TN) NCGC00015500-07 Haloperidol, European Pharmacopoeia (EP) Reference Standard SMR000058303 NCGC00015500-15 Halosten Spectrum_000861 NCGC00023875-06 HMS3261F08 Tocris-0931 NSC 170973 I14-14165 UNII-J6292F8L3D Opera_ID_446 KBio2_002390 [ Show all ]
Inchi Key	LNEPOXFFQSENCJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
PubChem CID	3559
ChEMBL	CHEMBL54
IUPHAR	86
BindingDB	21398
DrugBank	DB00502
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	55.0 nM	PMID9406603, PMID10377229, PMID7783131	BindingDB,ChEMBL
IC50	104.0 nM	PMID9876110	BindingDB,ChEMBL
IC50	125.0 nM	PMID12361392	BindingDB,ChEMBL
IC50	129.0 nM	PMID7914536	BindingDB,ChEMBL
Ki	15.84 nM	PMID7908055	BindingDB
Ki	19.95 nM	Bioorg. Med. Chem. Lett., (1997) 7:7:913, PMID10966742, PMID10425088, Bioorg. Med. Chem. Lett., (1995) 5:6:579, PMID9934473, PMID7914540	ChEMBL
Ki	20.0 nM	, PMID1347569, PMID8524985, PMID9934473	BindingDB
Ki	25.0 nM	PMID8935801, PMID9430133	BindingDB
Ki	26.8 nM	PMID8093723	BindingDB
Ki	27.0 nM	PMID7520908	BindingDB
Ki	28.0 nM	PMID9430133	BindingDB
Ki	34.0 nM	PMID9686407	BindingDB
Ki	34.67 nM	PMID17869521	ChEMBL
Ki	36.0 nM	PMID2869639	BindingDB
Ki	39.8107 nM	PMID9655845	IUPHAR
Ki	44.67 nM	PMID8568801	ChEMBL
Ki	45.0 nM	PMID8997630, PMID8568801	BindingDB,ChEMBL
Ki	49.0 nM	PMID12408724	BindingDB,ChEMBL
Ki	52.0 nM	PMID12482418	BindingDB
Ki	52.48 nM	PMID12482418, PMID11101359, PMID11754579	ChEMBL
Ki	72.0 nM	PMID8996185	BindingDB
Ki	75.0 nM	PMID9876110	BindingDB,ChEMBL
Ki	78.0 nM	PMID8822531	BindingDB
Ki	83.18 nM	PMID17300168	ChEMBL
Ki	87.0 nM	PMID8709107	BindingDB,ChEMBL
Ki	125.89 nM	PMID7984267	BindingDB
Ki	164.0 nM	PMID15771414, PMID11784139, PMID19072656, PMID14695828	BindingDB,ChEMBL
Ki	165.96 nM	PMID11784139	ChEMBL
Ki	549.54 nM	PMID9225287	BindingDB