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Name | 5-hydroxytryptamine receptor 6 |
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Species | Homo sapiens (Human) |
Gene | HTR6 |
Synonym | 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 [ Show all ] |
Disease | Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis [ Show all ] |
Length | 440 |
Amino acid sequence | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN |
UniProt | P50406 |
Protein Data Bank | N/A |
GPCR-HGmod model | P50406 |
3D structure model | This predicted structure model is from GPCR-EXP P50406. |
BioLiP | N/A |
Therapeutic Target Database | T16691 |
ChEMBL | CHEMBL3371 |
IUPHAR | 11 |
DrugBank | BE0000945 |
Name | SB-271046 |
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Molecular formula | C20H22ClN3O3S2 |
IUPAC name | 5-chloro-N-(4-methoxy-3-piperazin-1-ylphenyl)-3-methyl-1-benzothiophene-2-sulfonamide |
Molecular weight | 451.984 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 2 |
XlogP | 4.2 |
Synonyms | AKOS005266659 D07LRJ NCGC00386219-06 SB19511 SCHEMBL194700 [ Show all ] |
Inchi Key | LOCQRDBFWSXQQI-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C20H22ClN3O3S2/c1-13-16-11-14(21)3-6-19(16)28-20(13)29(25,26)23-15-4-5-18(27-2)17(12-15)24-9-7-22-8-10-24/h3-6,11-12,22-23H,7-10H2,1-2H3 |
PubChem CID | 5312149 |
ChEMBL | CHEMBL431298 |
IUPHAR | 276 |
BindingDB | 28583 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 2.0 nM | PMID24850589 | BindingDB |
IC50 | 2.0 nM | PMID24850589 | ChEMBL |
Kb | 5.8 nM | PMID24805037 | ChEMBL |
Ki | 0.66 nM | PMID19346128 | BindingDB,ChEMBL |
Ki | 0.8 nM | PMID15771424 | BindingDB,ChEMBL |
Ki | 0.81 nM | PMID14645659 | BindingDB |
Ki | 1.0 nM | PMID18053713, PMID15745826, PMID15974573, PMID12825922 | BindingDB,ChEMBL |
Ki | 1.259 nM | PMID21190848, PMID16143522, PMID11597412, PMID11992776 | ChEMBL |
Ki | 1.26 nM | PMID9925723 | IUPHAR |
Ki | 1.3 nM | PMID19433358, PMID24850589, PMID11597412, PMID10937732, PMID11992776 | BindingDB,ChEMBL |
Ki | 1.7 nM | PMID25637882 | BindingDB,ChEMBL |
Ki | 3.0 nM | PMID24878269 | ChEMBL |
Ki | 3.0 nM | PMID24878269 | BindingDB |
Ki | 3.02 nM | PMID24878269 | ChEMBL |
Ki | 13.0 nM | PMID19159187 | BindingDB,ChEMBL |
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