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GPCR

NameGastric inhibitory polypeptide receptor
SpeciesHomo sapiens (Human)
GeneGIPR
SynonymGIP-R
GIP receptor
Glucose-dependent insulinotropic polypeptide receptor
Gippr
DiseaseType 2 diabetes
Length466
Amino acid sequenceMTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
UniProtP48546
Protein Data BankN/A
GPCR-HGmod modelP48546
3D structure modelThis predicted structure model is from GPCR-EXP P48546.
BioLiPN/A
Therapeutic Target DatabaseT41750
ChEMBLCHEMBL4383
IUPHAR248
DrugBankN/A

Ligand

NameCHEMBL1644190
Molecular formulaC29H23F6N3O5
IUPAC name4-[[4-[[3,5-bis[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]methyl]benzoyl]amino]butanoic acid
Molecular weight607.509
Hydrogen bond acceptor12
Hydrogen bond donor2
XlogP6.6
SynonymsBDBM50334502
SCHEMBL12360133
4-(4-((3,5-bis(4-(trifluoromethoxy)phenyl)-1H-pyrazol-1-yl)methyl)benzamido)butanoic acid
Inchi KeyLORODLFSXFMEIM-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H23F6N3O5/c30-28(31,32)42-22-11-7-19(8-12-22)24-16-25(20-9-13-23(14-10-20)43-29(33,34)35)38(37-24)17-18-3-5-21(6-4-18)27(41)36-15-1-2-26(39)40/h3-14,16H,1-2,15,17H2,(H,36,41)(H,39,40)
PubChem CID10416258
ChEMBLCHEMBL1644190
IUPHARN/A
BindingDB50334502
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition15.0 %PMID21147532ChEMBL

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