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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
Trace amine receptor 12
Trace amine receptor 7b
TaR-7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3701915
Molecular formulaC15H15N5O
IUPAC name2-[4-[(2S)-morpholin-2-yl]anilino]pyrimidine-5-carbonitrile
Molecular weight281.319
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP0.8
SynonymsBDBM129374
SCHEMBL12609898
US8802673, 16
Inchi KeyLQKRWYFWHIWOMV-CQSZACIVSA-N
Inchi IDInChI=1S/C15H15N5O/c16-7-11-8-18-15(19-9-11)20-13-3-1-12(2-4-13)14-10-17-5-6-21-14/h1-4,8-9,14,17H,5-6,10H2,(H,18,19,20)/t14-/m1/s1
PubChem CID68325637
ChEMBLCHEMBL3701915
IUPHARN/A
BindingDB129374
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki448.3 nM, NoneBindingDB,ChEMBL

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