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GPCR

NameAlpha-2B adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdra2b
SynonymADRA2L1
alpha2B-adrenoceptor
alpha2B
alpha2-C2
alpha-2BAR
[ Show all ]
DiseaseN/A for non-human GPCRs
Length453
Amino acid sequenceMSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
UniProtP19328
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL266
IUPHAR26
DrugBankN/A

Ligand

NameCHEMBL309106
Molecular formulaC33H39N5O5
IUPAC name2-[4-(dimethylamino)phenyl]-N-[(2S)-2-hydroxy-3-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]propyl]-1,3-dioxoisoindole-5-carboxamide
Molecular weight585.705
Hydrogen bond acceptor8
Hydrogen bond donor2
XlogP3.6
SynonymsSCHEMBL6585005
BDBM50088394
RWJ-69442
2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid {2-hydroxy-3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propyl}-amide
Inchi KeyLQTJOPPTSIYEES-SANMLTNESA-N
Inchi IDInChI=1S/C33H39N5O5/c1-22(2)43-30-8-6-5-7-29(30)37-17-15-36(16-18-37)21-26(39)20-34-31(40)23-9-14-27-28(19-23)33(42)38(32(27)41)25-12-10-24(11-13-25)35(3)4/h5-14,19,22,26,39H,15-18,20-21H2,1-4H3,(H,34,40)/t26-/m0/s1
PubChem CID9894665
ChEMBLCHEMBL309106
IUPHARN/A
BindingDB50088394
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition73.0 %PMID10841797ChEMBL
Ki169.0 nMPMID10841797BindingDB,ChEMBL

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