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Name | Beta-2 adrenergic receptor |
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Species | Homo sapiens (Human) |
Gene | ADRB2 |
Synonym | beta-2 adrenergic receptor Gpcr7 beta2-adrenoceptor Adrb-2 ADRB2R [ Show all ] |
Disease | Premature labour Premature ejaculation Obesity Neurogenic bladder dysfunction Hypertension [ Show all ] |
Length | 413 |
Amino acid sequence | MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL |
UniProt | P07550 |
Protein Data Bank | 3nya, 3ny9, 3ny8, 3d4s, 2rh1, 3pds, 4gbr, 4lde, 6mxt, 6csy, 5x7d, 5jqh, 5d6l, 5d5b, 5d5a, 4ldo, 4ldl, 4qkx |
GPCR-HGmod model | P07550 |
3D structure model | This structure is from PDB ID 3nya. |
BioLiP | BL0257082, BL0113951, BL0113950, BL0257084, BL0257085, BL0283869, BL0333729, BL0333730, BL0333731,BL0333732,BL0333733, BL0333734, BL0333735, BL0333736,BL0333737,BL0333738, BL0113952,BL0113953,BL0113954, BL0147310, BL0257081, BL0257080, BL0232997, BL0192129, BL0257083, BL0185746,BL0185747, BL0185745, BL0185743,BL0185744, BL0185742, BL0185740,BL0185741, BL0147311,BL0147312, BL0351701,BL0351703, BL0351702,BL0351704, BL0192128, BL0433200, BL0433199, BL0430930, BL0430929, BL0388810, BL0388809, BL0354449, BL0185748, BL0354450, BL0354451,BL0354452,BL0354453, BL0388807,BL0388808 |
Therapeutic Target Database | T24555, T52522 |
ChEMBL | CHEMBL210 |
IUPHAR | 29 |
DrugBank | BE0000694 |
Name | (R,S)-(-)-fenoterol |
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Molecular formula | C17H21NO4 |
IUPAC name | 5-[(1R)-1-hydroxy-2-[[(2S)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol |
Molecular weight | 303.358 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 5 |
XlogP | 2.0 |
Synonyms | 5-[(R)-1-Hydroxy-2-[[(S)-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]resorcinol ZINC57319 BDBM50213106 (R,S)-Fenoterol D02QPP [ Show all ] |
Inchi Key | LSLYOANBFKQKPT-GTNSWQLSSA-N |
Inchi ID | InChI=1S/C17H21NO4/c1-11(6-12-2-4-14(19)5-3-12)18-10-17(22)13-7-15(20)9-16(21)8-13/h2-5,7-9,11,17-22H,6,10H2,1H3/t11-,17-/m0/s1 |
PubChem CID | 688467 |
ChEMBL | CHEMBL229476 |
IUPHAR | N/A |
BindingDB | 50213106 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 131.0 % | PMID24326276, PMID20036561 | ChEMBL |
EC50 | 4.7 nM | PMID20036561 | BindingDB,ChEMBL |
IC50 | 6.09 nM | , None | BindingDB,ChEMBL |
Kd | 3715.0 nM | , None | BindingDB,ChEMBL |
Ki | 183.0 nM | PMID24326276 | ChEMBL |
Ki | 183.23 nM | PMID24326276 | ChEMBL |
Ki | 3690.0 nM | PMID17506540 | ChEMBL |
Ki | 3695.0 nM | , None | BindingDB,ChEMBL |
Ki | 3700.0 nM | PMID17506540 | BindingDB |
Ki | 3715.35 nM | PMID17506540 | ChEMBL |
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