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GPCR

NameAlpha-2C adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdra2c
Synonymalpha2-C4
adrenergic receptor
Alpha-2C adrenoceptor
Adrenergic alpha2C- receptor class I
alpha2C-adrenoceptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length458
Amino acid sequenceMASPALAAALAAAAAEGPNGSDAGEWGSGGGANASGTDWGPPPGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYRRPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRGPAGPDGASPTTENGLGKAAGENGHCAPPRTEVEPDESSAAERRRRRGALRRGGRRREGAEGDTGSADGPGPGLAAEQGARTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProtP22086
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL314
IUPHARN/A
DrugBankN/A

Ligand

Namepericiazine
Molecular formulaC21H23N3OS
IUPAC name10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile
Molecular weight365.495
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP3.5
SynonymsPropericiazine
PERICYAZINE
Piperocyanomazine
Neuleptil
Nemactil
[ Show all ]
Inchi KeyLUALIOATIOESLM-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2
PubChem CID4747
ChEMBLN/A
IUPHAR9216
BindingDB50346422
DrugBankDB01608

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki160.0 nMPMID2876905BindingDB
Ki220.0 nMPMID2876905BindingDB
Ki2000.0 nMPMID2876905BindingDB
Ki3200.0 nMPMID2876905BindingDB

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