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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL1688472
Molecular formulaC25H26O3
IUPAC name3-[4-[[3-(2,6-dimethylphenyl)phenyl]methoxy]phenyl]butanoic acid
Molecular weight374.48
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.8
SynonymsBDBM50339475
3-{4-[(2'',6''-Dimethylbiphenyl-3-yl)methoxy]phenyl}butanoic Acid
Inchi KeyBBONBXQNPVADJZ-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H26O3/c1-17-6-4-7-18(2)25(17)22-9-5-8-20(15-22)16-28-23-12-10-21(11-13-23)19(3)14-24(26)27/h4-13,15,19H,14,16H2,1-3H3,(H,26,27)
PubChem CID51350137
ChEMBLCHEMBL1688472
IUPHARN/A
BindingDB50339475
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC5032.0 nMPMID21319751BindingDB,ChEMBL

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