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GPCR

NameHistamine H4 receptor
SpeciesHomo sapiens (Human)
GeneHRH4
SynonymPfi-013
SP9144
HH4R
H4R
H4 receptor
[ Show all ]
DiseaseAllergic rhinitis
Asthma
Inflammatory disease
Rheumatoid arthritis
Length390
Amino acid sequenceMPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
UniProtQ9H3N8
Protein Data BankN/A
GPCR-HGmod modelQ9H3N8
3D structure modelThis predicted structure model is from GPCR-EXP Q9H3N8.
BioLiPN/A
Therapeutic Target DatabaseT26500
ChEMBLCHEMBL3759
IUPHAR265
DrugBankBE0000146

Ligand

NameSCHEMBL603530
Molecular formulaC18H23N5
IUPAC name8-phenyl-4-piperazin-1-yl-5,6,7,8-tetrahydroquinazolin-2-amine
Molecular weight309.417
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.3
Synonyms8-phenyl-4-(piperazin-1-yl)-5,6,7,8-tetrahydroquinazolin-2-amine
CHEMBL1077256
LUZQAKHWJIHCHV-UHFFFAOYSA-N
Inchi KeyLUZQAKHWJIHCHV-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H23N5/c19-18-21-16-14(13-5-2-1-3-6-13)7-4-8-15(16)17(22-18)23-11-9-20-10-12-23/h1-3,5-6,14,20H,4,7-12H2,(H2,19,21,22)
PubChem CID44466872
ChEMBLCHEMBL1077256
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
pKb7.52 -PMID20171098ChEMBL

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