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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Rattus norvegicus (Rat)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProt	P14842
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL322
IUPHAR	6
DrugBank	N/A

Ligand

Name	alpha-methyl-5-HT
Molecular formula	C11H14N2O
IUPAC name	3-(2-aminopropyl)-1H-indol-5-ol
Molecular weight	190.246
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	0.6
Synonyms	CTK6A6964 NCGC00015629-03 PDSP2_001662 BDBM50014945 GTPL152 NCGC00024651-02 Alpha Methyl 5 Hydroxytryptamine BRD-A17745711-103-01-0 LYPCGXKCQDYTFV-UHFFFAOYSA-N PDSP1_001679 D09OYA NCGC00015629-04 SCHEMBL396996 AC1L1CXO Biomol-NT_000085 L001159 NCGC00024651-03 alpha-M-5-HT CCG-204907 CHEMBL275854 MB03476 PDSP2_001101 3-(2-aminopropyl)-1H-indol-5-ol alpha-Methylserotonin FT-0645249 NCGC00015629-05 AKOS022643479 BPBio1_001083 Lopac0_000823 PDSP1_001117 alpha-Me-5-HT CHEBI:48295 [ Show all ]
Inchi Key	LYPCGXKCQDYTFV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H14N2O/c1-7(12)4-8-6-13-11-3-2-9(14)5-10(8)11/h2-3,5-7,13-14H,4,12H2,1H3
PubChem CID	2107
ChEMBL	CHEMBL275854
IUPHAR	152
BindingDB	50014945
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	58.0 nM	PMID16392816	BindingDB,ChEMBL
EC50	184.0 nM	PMID12954071	BindingDB,ChEMBL
Efficacy	51.5 nM	PMID12954071	ChEMBL
Efficacy	98.0 %	PMID12954071	ChEMBL
Efficacy	99.0 %	PMID12954071	ChEMBL
Emax	96.0 %	PMID16392816	ChEMBL
IC50	1.5 nM	PMID12954071	BindingDB,ChEMBL
IC50	3.5 nM	PMID16392816	BindingDB,ChEMBL
Ki	1.0 nM	PMID12954071	BindingDB,ChEMBL
Ki	1258.93 nM	PMID11040033	IUPHAR

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