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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(3) dopamine receptor
Species	Chlorocebus aethiops (Green monkey)
Gene	DRD3
Synonym	Dopamine D3 receptor
Disease	N/A for non-human GPCRs
Length	400
Amino acid sequence	MAPLSQLSGHLNYTCGVENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRVCCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVTLMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDRAHLELKRYYSICQDTALGGPGFQERGGELKREERTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P52703
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2304406
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL147731
Molecular formula	C22H22N2
IUPAC name	4-phenyl-1-[(1-phenylpyrrol-3-yl)methyl]-3,6-dihydro-2H-pyridine
Molecular weight	314.432
Hydrogen bond acceptor	1
Hydrogen bond donor	0
XlogP	4.0
Synonyms	4-Phenyl-1-(1-phenyl-1H-pyrrol-3-ylmethyl)-1,2,3,6-tetrahydro-pyridine BDBM50048237 4-Phenyl-1-[(1-phenyl-1H-pyrrol-3-yl)methyl]-1,2,3,6-tetrahydropyridine
Inchi Key	LYPHIBLOFUSFAM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H22N2/c1-3-7-20(8-4-1)21-12-14-23(15-13-21)17-19-11-16-24(18-19)22-9-5-2-6-10-22/h1-12,16,18H,13-15,17H2
PubChem CID	10543298
ChEMBL	CHEMBL147731
IUPHAR	N/A
BindingDB	50048237
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	15.0 nM	PMID8523409	BindingDB,ChEMBL

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