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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL219968
Molecular formula	C30H32N4O6
IUPAC name	3-[[4-[[4-cyclohexyl-N-[(3-nitrophenyl)carbamoyl]anilino]methyl]benzoyl]amino]propanoic acid
Molecular weight	544.608
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	5.3
Synonyms	BDBM50202023 SCHEMBL2663164 3-(4-((1-(4-cyclohexylphenyl)-3-(3-nitrophenyl)ureido)methyl)benzamido)propanoic acid
Inchi Key	BCBSZTWGAUGXNY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H32N4O6/c35-28(36)17-18-31-29(37)24-11-9-21(10-12-24)20-33(30(38)32-25-7-4-8-27(19-25)34(39)40)26-15-13-23(14-16-26)22-5-2-1-3-6-22/h4,7-16,19,22H,1-3,5-6,17-18,20H2,(H,31,37)(H,32,38)(H,35,36)
PubChem CID	16100314
ChEMBL	CHEMBL219968
IUPHAR	N/A
BindingDB	50202023
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	167.0 nM	PMID17201415	BindingDB,ChEMBL

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