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GPCR

NameProstaglandin E2 receptor EP4 subtype
SpeciesRattus norvegicus (Rat)
GenePtger4
SynonymEP2
EP4 receptor
PGE receptor EP4 subtype
PGE2 receptor EP4 subtype
Prostanoid EP4 receptor
DiseaseN/A for non-human GPCRs
Length488
Amino acid sequenceMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
UniProtP43114
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4086
IUPHAR343
DrugBankN/A

Ligand

NameCHEMBL382197
Molecular formulaC28H31NO4S
IUPAC name5-[3-[(2S)-2-[3-hydroxy-4-(3-phenylphenyl)butyl]-5-oxopyrrolidin-1-yl]propyl]thiophene-2-carboxylic acid
Molecular weight477.619
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP5.4
SynonymsSCHEMBL4992003
BDBM50181290
5-{3-[(S)-2-(4-biphenyl-3-yl-3-hydroxy-butyl)-5-oxo-pyrrolidin-1-yl]-propyl}-thiophene-2-carboxylic acid
Inchi KeyBCBYBNIDJGIOQL-UXMRNZNESA-N
Inchi IDInChI=1S/C28H31NO4S/c30-24(19-20-6-4-9-22(18-20)21-7-2-1-3-8-21)13-11-23-12-16-27(31)29(23)17-5-10-25-14-15-26(34-25)28(32)33/h1-4,6-9,14-15,18,23-24,30H,5,10-13,16-17,19H2,(H,32,33)/t23-,24?/m0/s1
PubChem CID44409910
ChEMBLCHEMBL382197
IUPHARN/A
BindingDB50181290
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Activity95.0 %PMID16442794ChEMBL
EC50203.0 nMPMID16442794BindingDB,ChEMBL
IC5050.0 nMPMID16442794BindingDB,ChEMBL

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