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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	C-C chemokine receptor type 8
Species	Homo sapiens (Human)
Gene	CCR8
Synonym	GPRCY6 GPR-CY6 CMKBRL2 CKR-L1 ChemR1 Chemokine receptor-like 1 CCR8 CCR-8 CC-CKR-8 CC chemokine receptor CHEMR1 C-C CKR-8 TER1 [ Show all ]
Disease	Psoriasis
Length	355
Amino acid sequence	MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
UniProt	P51685
Protein Data Bank	N/A
GPCR-HGmod model	P51685
3D structure model	This predicted structure model is from GPCR-EXP P51685.
BioLiP	N/A
Therapeutic Target Database	T20575
ChEMBL	CHEMBL4596
IUPHAR	65
DrugBank	N/A

Ligand

Name	CHEMBL395423
Molecular formula	C26H26N4O3
IUPAC name	4-[[4-[5-(6-methoxyquinolin-4-yl)-2-oxo-1,3-oxazolidin-3-yl]piperidin-1-yl]methyl]benzonitrile
Molecular weight	442.519
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	3.5
Synonyms	BDBM50423247
Inchi Key	LZRXJGYRQJPRJM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H26N4O3/c1-32-21-6-7-24-23(14-21)22(8-11-28-24)25-17-30(26(31)33-25)20-9-12-29(13-10-20)16-19-4-2-18(15-27)3-5-19/h2-8,11,14,20,25H,9-10,12-13,16-17H2,1H3
PubChem CID	44439895
ChEMBL	CHEMBL395423
IUPHAR	N/A
BindingDB	50423247
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	12589.0 nM	PMID17267215	BindingDB
IC50	12589.2 nM	PMID17267215	ChEMBL

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