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GPCR

NameAlpha-1D adrenergic receptor
SpeciesHomo sapiens (Human)
GeneADRA1D
SynonymAlpha-adrenergic receptor 1a
Gpcr8
alpha1A/D
alpha1D-adrenoceptor
alpha 1D-adrenoceptor
[ Show all ]
DiseasePediatric cancer
Prostate hyperplasia
Prostate disease
Peripheral vascular disease
Hypertension
[ Show all ]
Length572
Amino acid sequenceMTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI
UniProtP25100
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseT53381
ChEMBLCHEMBL223
IUPHAR24
DrugBankBE0000715, BE0004863

Ligand

NameCHEMBL72768
Molecular formulaC11H14FN3S
IUPAC nameN-(4,5-dihydro-1H-imidazol-2-ylmethyl)-5-fluoro-2-methylsulfanylaniline
Molecular weight239.312
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP1.5
SynonymsN/A
Inchi KeyBCCMUPQZPVRDCD-UHFFFAOYSA-N
Inchi IDInChI=1S/C11H14FN3S/c1-16-10-3-2-8(12)6-9(10)15-7-11-13-4-5-14-11/h2-3,6,15H,4-5,7H2,1H3,(H,13,14)
PubChem CID11140347
ChEMBLCHEMBL72768
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5021.88 nMPMID12014961ChEMBL
Ki6.166 nMPMID12014961ChEMBL
Max107.0 %PMID12014961ChEMBL

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