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Name | Prostaglandin E2 receptor EP4 subtype |
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Species | Homo sapiens (Human) |
Gene | PTGER4 |
Synonym | Prostanoid EP4 receptor PGE2 receptor EP4 subtype PGE receptor EP4 subtype EP4 receptor EP2 |
Disease | Ulcerative colitis Glaucoma Inflammatory disease Migraine Osteoarthritis [ Show all ] |
Length | 488 |
Amino acid sequence | MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI |
UniProt | P35408 |
Protein Data Bank | 5ywy, 5yhl |
GPCR-HGmod model | P35408 |
3D structure model | This structure is from PDB ID 5ywy. |
BioLiP | BL0434347, BL0434289 |
Therapeutic Target Database | T18876 |
ChEMBL | CHEMBL1836 |
IUPHAR | 343 |
DrugBank | BE0003522 |
Name | CHEMBL413563 |
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Molecular formula | C24H35NO5 |
IUPAC name | 7-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]but-1-enyl]-6-oxopiperidin-1-yl]heptanoic acid |
Molecular weight | 417.546 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | 2.6 |
Synonyms | 7-{(R)-2-[(E)-(S)-3-Hydroxy-4-(3-methoxymethyl-phenyl)-but-1-enyl]-6-oxo-piperidin-1-yl}-heptanoic acid BDBM50166472 SCHEMBL4934128 |
Inchi Key | BCCRAFCMMIFCKU-WRBWEIJPSA-N |
Inchi ID | InChI=1S/C24H35NO5/c1-30-18-20-9-6-8-19(16-20)17-22(26)14-13-21-10-7-11-23(27)25(21)15-5-3-2-4-12-24(28)29/h6,8-9,13-14,16,21-22,26H,2-5,7,10-12,15,17-18H2,1H3,(H,28,29)/b14-13+/t21-,22-/m1/s1 |
PubChem CID | 11742697 |
ChEMBL | CHEMBL413563 |
IUPHAR | N/A |
BindingDB | 50166472 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 44.0 nM | PMID15863309 | BindingDB,ChEMBL |
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