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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Sus scrofa (Pig)
Gene	HTR2A
Synonym	5-HT-2 5-HT-2A 5-HT2A Serotonin receptor 2A
Disease	N/A for non-human GPCRs
Length	470
Amino acid sequence	MDVLCEENTSLSSPTNSFMQLNDDTRLYHNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHRRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQTGQKENSKQDDKATENDCTMVALGKQHSEDAPADNSNTVNEKVSCV
UniProt	P50129
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2490
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL1256171
Molecular formula	C41H47N3O
IUPAC name	N-[4-[4-(5-tricyclo[8.2.2.24,7]hexadeca-1(13),4,6,10(14),11,15-hexaenyl)piperazin-1-yl]butyl]tricyclo[8.2.2.24,7]hexadeca-1(13),4,6,10(14),11,15-hexaene-5-carboxamide
Molecular weight	597.847
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	8.6
Synonyms	N-[4-[4-([2.2]Paracyclophan-4-yl)piperazin-1-yl]butyl][2.2]paracyclophanyl-4-carboxamide BDBM50328458
Inchi Key	MAMYYNBMHYGSHM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C41H47N3O/c45-41(39-29-35-13-11-31-3-7-33(8-4-31)15-19-37(39)20-17-35)42-23-1-2-24-43-25-27-44(28-26-43)40-30-36-14-12-32-5-9-34(10-6-32)16-21-38(40)22-18-36/h3-10,17-18,20,22,29-30H,1-2,11-16,19,21,23-28H2,(H,42,45)
PubChem CID	49783041
ChEMBL	CHEMBL1256171
IUPHAR	N/A
BindingDB	50328458
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	8200.0 nM	PMID20839776	BindingDB,ChEMBL

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