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GPCR

NameTrace amine-associated receptor 1
SpeciesMus musculus (Mouse)
GeneTaar1
SynonymTRAR1
TA1 receptor
TAR1
trace amine receptor 1
TaR-1
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProtQ923Y8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4908
IUPHAR364
DrugBankN/A

Ligand

NameCHEMBL3701982
Molecular formulaC17H20ClN3O
IUPAC name5-chloro-4-methyl-N-(2-methyl-4-morpholin-2-ylphenyl)pyridin-2-amine
Molecular weight317.817
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP3.1
SynonymsSCHEMBL12609660
BDBM129442
US8802673, 84
Inchi KeyMBMKHZBDODIGFV-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H20ClN3O/c1-11-8-17(20-9-14(11)18)21-15-4-3-13(7-12(15)2)16-10-19-5-6-22-16/h3-4,7-9,16,19H,5-6,10H2,1-2H3,(H,20,21)
PubChem CID68325453
ChEMBLCHEMBL3701982
IUPHARN/A
BindingDB129442
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki1.5 nM, NoneBindingDB,ChEMBL

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