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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
Trace amine receptor 12
Trace amine receptor 7b
TaR-7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3701980
Molecular formulaC15H17ClN4O
IUPAC name5-chloro-N-(2-methyl-4-morpholin-2-ylphenyl)pyrimidin-2-amine
Molecular weight304.778
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.1
SynonymsSCHEMBL12609936
BDBM129439
US8802673, 81
Inchi KeyMBUMJWNHWGAIBT-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H17ClN4O/c1-10-6-11(14-9-17-4-5-21-14)2-3-13(10)20-15-18-7-12(16)8-19-15/h2-3,6-8,14,17H,4-5,9H2,1H3,(H,18,19,20)
PubChem CID68325667
ChEMBLCHEMBL3701980
IUPHARN/A
BindingDB129439
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki202.7 nM, NoneBindingDB,ChEMBL

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