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Name | Delta-type opioid receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | OPRD1 |
Synonym | D-OR-1 DOR opioid receptor OP1 DOP [ Show all ] |
Disease | Cough Overactive bladder disorder Bladder disease Moderate-to-severe pain Diarrhea-predominant IBS [ Show all ] |
Length | 372 |
Amino acid sequence | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA |
UniProt | P41143 |
Protein Data Bank | 4rwd, 4rwa, 4n6h |
GPCR-HGmod model | P41143 |
3D structure model | This structure is from PDB ID 4rwd. |
BioLiP | BL0303696,BL0303697, BL0265712, BL0265705,BL0265706,BL0265707,, BL0303699,BL0303701, BL0303698,BL0303700 |
Therapeutic Target Database | T58992 |
ChEMBL | CHEMBL236 |
IUPHAR | 317 |
DrugBank | BE0000420 |
Name | DPDPE |
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Molecular formula | C30H39N5O7S2 |
IUPAC name | (4S,7S,13S)-13-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid |
Molecular weight | 645.79 |
Hydrogen bond acceptor | 10 |
Hydrogen bond donor | 7 |
XlogP | -0.6 |
Synonyms | c[D-Pen(2,5)]-enkephalin Enkephalin, [Tyrosyl-2,6-3H(N)]- (2-D-Penicillamine, 5-D-Penicillamine) Pen(2),pen(5)-enkephalin [D-Pen2,5]-Enkephalin hydrate (D-Pen(2),D-pen(5))enkephalin [ Show all ] |
Inchi Key | MCMMCRYPQBNCPH-WMIMKTLMSA-N |
Inchi ID | InChI=1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21-,23-,24-/m0/s1 |
PubChem CID | 104787 |
ChEMBL | CHEMBL31421 |
IUPHAR | 1608 |
BindingDB | 21008 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 0.12 nM | PMID27096047 | BindingDB |
EC50 | 0.12 nM | PMID27096047 | ChEMBL |
EC50 | 1.6 nM | PMID16686530, PMID17927164, PMID18266313 | BindingDB |
EC50 | 8.0 nM | PMID26048798 | BindingDB |
EC50 | 8.01 nM | PMID26048798 | ChEMBL |
EC50 | 13.2 nM | PMID26525865 | ChEMBL |
EC50 | 16.98 nM | PMID26944625 | ChEMBL |
EC50 | 17.0 nM | PMID26944625 | BindingDB |
EC50 | 21.0 nM | PMID17350835 | BindingDB,ChEMBL |
EC50 | 26.92 nM | PMID26785295 | ChEMBL |
EC50 | 27.0 nM | PMID26785295 | BindingDB |
Emax | 100.0 % | PMID26048798 | ChEMBL |
Emax | 216.0 % | PMID27096047 | ChEMBL |
IC50 | 1.3 nM | PMID27876250 | BindingDB,ChEMBL |
Kd | 0.45 nM | PMID18266313 | BindingDB |
Kd | 0.5 nM | PMID16686530, PMID17927164 | BindingDB |
Ki | 0.3 nM | PMID9686407 | BindingDB |
Ki | 0.87 nM | PMID7932177 | BindingDB |
Ki | 1.58489 nM | PMID9686407, PMID6310598 | IUPHAR |
Ki | 1.6 nM | PMID17539621 | BindingDB |
Ki | 1.7 nM | PMID9686407 | BindingDB |
Ki | 3.2 nM | PMID17350835 | BindingDB,ChEMBL |
Ki | 14.0 nM | PMID8114680 | BindingDB |
Ki | 14.5 nM | PMID11961071 | BindingDB |
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