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GPCR

NameSomatostatin receptor type 5
SpeciesHomo sapiens (Human)
GeneSSTR5
SynonymSOMATO
SS-5-R
SS5-R
SS5R
SST5 receptor
DiseaseN/A
Length364
Amino acid sequenceMEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPAHRAAANGLMQTSKL
UniProtP35346
Protein Data BankN/A
GPCR-HGmod modelP35346
3D structure modelThis predicted structure model is from GPCR-EXP P35346.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1792
IUPHAR359
DrugBankBE0002147

Ligand

NameCHEMBL393515
Molecular formulaC32H33FN4O2
IUPAC nameN-[1-[(1,4-dimethoxynaphthalen-2-yl)methyl]piperidin-4-yl]-1-[(4-fluorophenyl)methyl]benzimidazol-2-amine
Molecular weight524.64
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP6.7
SynonymsBDBM50227124
1-(4-fluorobenzyl)-N-(1-((1,4-dimethoxynaphthalen-2-yl)methyl)piperidin-4-yl)-1H-benzo[d]imidazol-2-amine
Inchi KeyBCHRCFZHJDSRAB-UHFFFAOYSA-N
Inchi IDInChI=1S/C32H33FN4O2/c1-38-30-19-23(31(39-2)27-8-4-3-7-26(27)30)21-36-17-15-25(16-18-36)34-32-35-28-9-5-6-10-29(28)37(32)20-22-11-13-24(33)14-12-22/h3-14,19,25H,15-18,20-21H2,1-2H3,(H,34,35)
PubChem CID24740636
ChEMBLCHEMBL393515
IUPHARN/A
BindingDB50227124
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki1230.0 nMPMID18020390BindingDB,ChEMBL

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