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GPCR

NameHistamine H4 receptor
SpeciesRattus norvegicus (Rat)
GeneHrh4
SynonymH4 receptor
H4R
HH4R
GPCR105
DiseaseN/A for non-human GPCRs
Length391
Amino acid sequenceMSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
UniProtQ91ZY1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4468
IUPHAR265
DrugBankN/A

Ligand

NameCHEMBL494667
Molecular formulaC12H17N7
IUPAC name4-(1H-imidazol-5-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine
Molecular weight259.317
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP0.0
SynonymsSCHEMBL2167051
Inchi KeyMCSLSGYTPAVGEY-UHFFFAOYSA-N
Inchi IDInChI=1S/C12H17N7/c1-18-2-4-19(5-3-18)11-6-9(16-12(13)17-11)10-7-14-8-15-10/h6-8H,2-5H2,1H3,(H,14,15)(H2,13,16,17)
PubChem CID25131559
ChEMBLCHEMBL494667
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50389.05 nMPMID18811133ChEMBL
Efficacy77.0 %PMID18811133ChEMBL

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