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Name | Gonadotropin-releasing hormone receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Gnrhr |
Synonym | luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor LHRHR LHRH receptor GNRHR1 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 327 |
Amino acid sequence | MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL |
UniProt | P30969 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3066 |
IUPHAR | 256 |
DrugBank | N/A |
Name | CHEMBL297927 |
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Molecular formula | C35H45N3O4S |
IUPAC name | ethyl 2-[2-(3,5-dimethylphenyl)-3-[2-[4-[4-(methanesulfonamido)phenyl]butylamino]ethyl]-1H-indol-5-yl]-2-methylpropanoate |
Molecular weight | 603.822 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 3 |
XlogP | 7.0 |
Synonyms | 2-(2-(3,5-dimethylphenyl)-3-{2-[4-(4-methanesulfonylaminophenyl)butylamino]ethyl}-1H-indol-5-yl)-2-methylpropionic acid ethyl ester BCIRPBHKMMHSSH-UHFFFAOYSA-N 2-(2-(3,5-dimethylphenyl)-3-{2-[4-(4-methanesulfonylamino-phenyl)butylamino]ethyl}-1H-indol-5-yl)-2-methylpropionic acid ethyl ester BDBM50101167 2-(2-(3,5-dimethylphenyl)-3-{2-[4-(4-methanesulfonylamino-phenyl)butylamino]ethyl}-1H-indol-5yl)-2-methylpropionic acid ethyl ester [ Show all ] |
Inchi Key | BCIRPBHKMMHSSH-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C35H45N3O4S/c1-7-42-34(39)35(4,5)28-13-16-32-31(23-28)30(33(37-32)27-21-24(2)20-25(3)22-27)17-19-36-18-9-8-10-26-11-14-29(15-12-26)38-43(6,40)41/h11-16,20-23,36-38H,7-10,17-19H2,1-6H3 |
PubChem CID | 44293054 |
ChEMBL | CHEMBL297927 |
IUPHAR | N/A |
BindingDB | 50101167 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 0.3 nM | PMID11425546 | ChEMBL |
IC50 | 0.3 nM | PMID11425546 | BindingDB |
IC50 | 3.0 nM | PMID11425546 | BindingDB,ChEMBL |
IC50 | 150.0 nM | PMID11425546 | BindingDB,ChEMBL |
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