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GPCR

Name5-hydroxytryptamine receptor 6
SpeciesRattus norvegicus (Rat)
GeneHtr6
Synonym5-HT-6
5-HT6
5-HT6 receptor
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
Serotonin receptor 6
[ Show all ]
DiseaseN/A for non-human GPCRs
Length436
Amino acid sequenceMVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
UniProtP31388
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3372
IUPHAR11
DrugBankN/A

Ligand

NamePENFLURIDOL
Molecular formulaC28H27ClF5NO
IUPAC name1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-ol
Molecular weight523.972
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP7.3
Synonyms1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol
Penfluridol (USAN/INN)
26864-56-2
PubChem15873
5-21-02-00409 (Beilstein Handbook Reference)
[ Show all ]
Inchi KeyMDLAAYDRRZXJIF-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2
PubChem CID33630
ChEMBLN/A
IUPHARN/A
BindingDB50026066
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki5000.0 nMPMID7908055BindingDB

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