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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin D2 receptor
Species	Homo sapiens (Human)
Gene	PTGDR
Synonym	PGD2 receptor DP1 DP1 receptor PTGDR1 prostanoid DP receptor-like Prostanoid DP receptor prostaglandin D2 receptor (DP) PGD receptor [ Show all ]
Disease	Pain Dyslipidaemias Rhinitis Thromboembolism Thrombosis Atopic dermatitis Asthma Allergy Allergic rhinitis [ Show all ]
Length	359
Amino acid sequence	MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
UniProt	Q13258
Protein Data Bank	N/A
GPCR-HGmod model	Q13258
3D structure model	This predicted structure model is from GPCR-EXP Q13258.
BioLiP	N/A
Therapeutic Target Database	T68782
ChEMBL	CHEMBL4427
IUPHAR	338
DrugBank	BE0000296

Ligand

Name	CHEMBL83485
Molecular formula	C26H31NO4S
IUPAC name	(Z)-7-[(1S,2R,3R,4R)-3-[(2-phenylphenyl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acid
Molecular weight	453.597
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	5.2
Synonyms	(+) 7-[3-(Biphenyl-2-sulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid BDBM50128720
Inchi Key	BCLHVIXHPNNBKL-ZYPSWUJOSA-N
Inchi ID	InChI=1S/C26H31NO4S/c28-25(29)15-7-2-1-6-13-23-20-16-17-21(18-20)26(23)27-32(30,31)24-14-9-8-12-22(24)19-10-4-3-5-11-19/h1,3-6,8-12,14,20-21,23,26-27H,2,7,13,15-18H2,(H,28,29)/b6-1-/t20-,21+,23+,26+/m0/s1
PubChem CID	11102462
ChEMBL	CHEMBL83485
IUPHAR	N/A
BindingDB	50128720
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	8600.0 nM	PMID12773047	BindingDB,ChEMBL

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