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GLASS

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GPCR

Name	Galanin receptor type 2
Species	Homo sapiens (Human)
Gene	GALR2
Synonym	GAL2 receptor GAL2-R GALNR2 GALR-2
Disease	N/A
Length	387
Amino acid sequence	MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProt	O43603
Protein Data Bank	N/A
GPCR-HGmod model	O43603
3D structure model	This predicted structure model is from GPCR-EXP O43603.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3176
IUPHAR	244
DrugBank	N/A

Ligand

Name	MLS000567024
Molecular formula	C14H9N3S
IUPAC name	(E)-2-(1H-benzimidazol-2-yl)-3-thiophen-2-ylprop-2-enenitrile
Molecular weight	251.307
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.0
Synonyms	(E)-2-(1H-benzimidazol-2-yl)-3-(2-thienyl)acrylonitrile AB00088886-01 cid_5334847 SR-01000046927-1 (E)-2-(1H-benzimidazol-2-yl)-3-thiophen-2-ylprop-2-enenitrile BAS 00442707 MDVSLHGZTWHJMW-CSKARUKUSA-N (2E)-2-(1H-Benzimidazol-2-yl)-3-(2-thienyl)-2-propenenitrile # 2-(1H-benzo[d]imidazol-2-yl)-3-(2-thienyl)acrylonitrile SMR000175048 (E)-2-(1H-benzimidazol-2-yl)-3-thiophen-2-yl-2-propenenitrile AC1NSIYA HMS2553D06 ST50728509 1H-Benzimidazole-2-acetonitrile, .alpha.-(2-thienylmethylene)- BDBM42055 (2E)-2-benzimidazol-2-yl-3-(2-thienyl)prop-2-enenitrile CHEMBL116569 SR-01000046927 (E)-2-(1H-benzimidazol-2-yl)-3-thiophen-2-yl-prop-2-enenitrile AKOS000541721 HMS552K09 ZINC4301938 2-(1H-Benzoimidazol-2-yl)-3-thiophen-2-yl-acrylonitrile Cambridge id 5554994 MolPort-000-305-212 [ Show all ]
Inchi Key	MDVSLHGZTWHJMW-CSKARUKUSA-N
Inchi ID	InChI=1S/C14H9N3S/c15-9-10(8-11-4-3-7-18-11)14-16-12-5-1-2-6-13(12)17-14/h1-8H,(H,16,17)/b10-8+
PubChem CID	5334847
ChEMBL	CHEMBL116569
IUPHAR	N/A
BindingDB	42055
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<42000.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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