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GPCR

NameNociceptin receptor
SpeciesMus musculus (Mouse)
GeneOprl1
SynonymNOP receptor
NOP-r
NOPr
OP4
ORGC
[ Show all ]
DiseaseN/A for non-human GPCRs
Length367
Amino acid sequenceMESLFPAPFWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
UniProtP35377
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3621
IUPHAR320
DrugBankN/A

Ligand

NameCHEMBL411168
Molecular formulaC62H102N22O15
IUPAC name(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[2-[[(2S,3R)-3-hydroxy-2-[[(2S)-2-[[2-[[2-[[2-[(4-methylphenyl)methylamino]acetyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]butanoyl]amino]acetyl]amino]propanoyl]amino]pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Molecular weight1395.64
Hydrogen bond acceptor20
Hydrogen bond donor22
XlogP-6.6
SynonymsN/A
Inchi KeyMEPSQOOWEQUSDG-JDSHJPIKSA-N
Inchi IDInChI=1S/C62H102N22O15/c1-35-20-22-40(23-21-35)29-70-30-47(87)73-31-48(88)74-32-50(90)78-45(28-39-14-6-5-7-15-39)58(97)84-51(38(4)86)60(99)75-33-49(89)76-36(2)53(92)80-44(19-13-27-72-62(68)69)56(95)82-42(17-9-11-25-64)57(96)83-46(34-85)59(98)77-37(3)54(93)81-43(18-12-26-71-61(66)67)55(94)79-41(52(65)91)16-8-10-24-63/h5-7,14-15,20-23,36-38,41-46,51,70,85-86H,8-13,16-19,24-34,63-64H2,1-4H3,(H2,65,91)(H,73,87)(H,74,88)(H,75,99)(H,76,89)(H,77,98)(H,78,90)(H,79,94)(H,80,92)(H,81,93)(H,82,95)(H,83,96)(H,84,97)(H4,66,67,71)(H4,68,69,72)/t36-,37-,38+,41-,42-,43-,44-,45-,46-,51-/m0/s1
PubChem CID10844105
ChEMBLCHEMBL411168
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki2511.89 nMPMID10956188ChEMBL

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