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Name | Gastrin-releasing peptide receptor |
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Species | Homo sapiens (Human) |
Gene | GRPR |
Synonym | GRP-R GRP-preferring bombesin receptor gastrin-releasing peptide receptor BB2 receptor BB2 |
Disease | Solid tumours Breast cancer Cancer Irritable bowel syndrome |
Length | 384 |
Amino acid sequence | MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTSLKSTNPSVATFSLINGNICHERYV |
UniProt | P30550 |
Protein Data Bank | N/A |
GPCR-HGmod model | P30550 |
3D structure model | This predicted structure model is from GPCR-EXP P30550. |
BioLiP | N/A |
Therapeutic Target Database | T99816 |
ChEMBL | CHEMBL4959 |
IUPHAR | 39 |
DrugBank | N/A |
Name | CHEMBL1907865 |
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Molecular formula | C35H42N4O2 |
IUPAC name | (2R)-2-[[2,6-di(propan-2-yl)phenyl]carbamoylamino]-3-(1H-indol-3-yl)-2-methyl-N-(1,2,3,4-tetrahydronaphthalen-1-yl)propanamide |
Molecular weight | 550.747 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 4 |
XlogP | 7.1 |
Synonyms | BDBM50366467 |
Inchi Key | BCUIXRZIPCRVGV-NOUYKBLCSA-N |
Inchi ID | InChI=1S/C35H42N4O2/c1-22(2)26-16-11-17-27(23(3)4)32(26)38-34(41)39-35(5,20-25-21-36-30-18-9-8-15-29(25)30)33(40)37-31-19-10-13-24-12-6-7-14-28(24)31/h6-9,11-12,14-18,21-23,31,36H,10,13,19-20H2,1-5H3,(H,37,40)(H2,38,39,41)/t31?,35-/m1/s1 |
PubChem CID | 57402754 |
ChEMBL | CHEMBL1907865 |
IUPHAR | N/A |
BindingDB | 50366467 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | <10000.0 nM | , Bioorg. Med. Chem. Lett., (1996) 6:21:2617 | BindingDB,ChEMBL |
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