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GLASS

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GPCR

Name	Somatostatin receptor type 5
Species	Homo sapiens (Human)
Gene	SSTR5
Synonym	SOMATO SS-5-R SS5-R SS5R SST5 receptor
Disease	N/A
Length	364
Amino acid sequence	MEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPAHRAAANGLMQTSKL
UniProt	P35346
Protein Data Bank	N/A
GPCR-HGmod model	P35346
3D structure model	This predicted structure model is from GPCR-EXP P35346.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1792
IUPHAR	359
DrugBank	BE0002147

Ligand

Name	SCHEMBL671295
Molecular formula	C27H31N3O5
IUPAC name	4-[8-[(6-methoxy-1-propan-2-ylindol-3-yl)methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid
Molecular weight	477.561
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	1.4
Synonyms	US8742110, 6-16 CHEMBL3670746 BDBM123298
Inchi Key	BDAJGWJEZRTMNP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H31N3O5/c1-18(2)29-16-20(23-9-8-22(34-3)14-24(23)29)15-28-12-10-27(11-13-28)17-30(26(33)35-27)21-6-4-19(5-7-21)25(31)32/h4-9,14,16,18H,10-13,15,17H2,1-3H3,(H,31,32)
PubChem CID	66765212
ChEMBL	CHEMBL3670746
IUPHAR	N/A
BindingDB	123298
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	0.8512 nM	, None	BindingDB,ChEMBL

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