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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3220233
Molecular formula	C22H24N8O4
IUPAC name	4-[[2-[(2R)-4-[5-(1,4-dioxan-2-yl)-1,2,4-oxadiazol-3-yl]-2-methylpiperazin-1-yl]pyrimidin-5-yl]oxymethyl]pyridine-3-carbonitrile
Molecular weight	464.486
Hydrogen bond acceptor	12
Hydrogen bond donor	0
XlogP	0.7
Synonyms	N/A
Inchi Key	BDCALHIYMZXLRA-NYRJJRHWSA-N
Inchi ID	InChI=1S/C22H24N8O4/c1-15-12-29(22-27-20(34-28-22)19-14-31-6-7-32-19)4-5-30(15)21-25-10-18(11-26-21)33-13-16-2-3-24-9-17(16)8-23/h2-3,9-11,15,19H,4-7,12-14H2,1H3/t15-,19?/m1/s1
PubChem CID	90666908
ChEMBL	CHEMBL3220233
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

Parameter	Value	Reference	Database source
EC50	100.0 nM	MedChemComm, (2013) 4:1:95	ChEMBL
Intrinsic activity	279.0 %	MedChemComm, (2013) 4:1:95	ChEMBL

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