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GPCR

NameNeuropeptide Y receptor type 5
SpeciesHomo sapiens (Human)
GeneNPY5R
SynonymNPYY5-R
NPY5-R
NPY-Y5 receptor
neuropeptide Y receptor type 5
food intake receptor
[ Show all ]
DiseaseEating disorder; Obesity
Eating disorder; Obesity; Diabetes
Major depressive disorder
Obesity
Length445
Amino acid sequenceMDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProtQ15761
Protein Data BankN/A
GPCR-HGmod modelQ15761
3D structure modelThis predicted structure model is from GPCR-EXP Q15761.
BioLiPN/A
Therapeutic Target DatabaseT20331
ChEMBLCHEMBL4561
IUPHAR308
DrugBankN/A

Ligand

NameCHEMBL491930
Molecular formulaC23H20N4O3
IUPAC name3-oxo-N-(5-phenylpyrazin-2-yl)spiro[2-benzofuran-1,4'-piperidine]-1'-carboxamide
Molecular weight400.438
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP2.4
SynonymsSCHEMBL918154
MKVJQAZEXGSAIT-UHFFFAOYSA-N
3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[isobenzofuran-1,4''-piperidine]-1''-carboxamide
BDBM50249869
SPIRO[ISOBENZOFURAN-1(3H),4'-PIPERIDINE]-1'-CARBOXAMIDE, 3-OXO-N-(5-PHENYL-2-PYRAZINYL)-
[ Show all ]
Inchi KeyMKVJQAZEXGSAIT-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H20N4O3/c28-21-17-8-4-5-9-18(17)23(30-21)10-12-27(13-11-23)22(29)26-20-15-24-19(14-25-20)16-6-2-1-3-7-16/h1-9,14-15H,10-13H2,(H,25,26,29)
PubChem CID9887225
ChEMBLCHEMBL491930
IUPHARN/A
BindingDB50249869
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC502.4 nMPMID19464889BindingDB,ChEMBL
IC506.1 nMPMID19464889BindingDB,ChEMBL
Ki2.4 nMPMID19459652BindingDB,ChEMBL

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