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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL457275
Molecular formula	C19H21NO4
IUPAC name	(6aR)-2-(2-hydroxyethoxy)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
Molecular weight	327.38
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	1.6
Synonyms	[R-(-)-Apomorphine-2-yl]-(2'-hydroxy-ethyl)ether BDBM50251328 D0Z9JY [R-(-)-Apomorphine-2-yl]-(2''-hydroxy-ethyl)ether
Inchi Key	MLSWBRKIYGJEGT-OAHLLOKOSA-N
Inchi ID	InChI=1S/C19H21NO4/c1-20-5-4-12-8-13(24-7-6-21)10-14-17(12)15(20)9-11-2-3-16(22)19(23)18(11)14/h2-3,8,10,15,21-23H,4-7,9H2,1H3/t15-/m1/s1
PubChem CID	44567595
ChEMBL	CHEMBL457275
IUPHAR	N/A
BindingDB	50251328
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	315.0 nM	PMID18313931	BindingDB,ChEMBL
Efficacy	19.0 %	PMID18313931	ChEMBL
Ki	347.0 nM	PMID18313931	BindingDB,ChEMBL

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