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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Rattus norvegicus (Rat)
Gene	Chrm4
Synonym	cholinergic receptor cholinergic receptor, muscarinic 4 Chrm-4 HM3 M4 receptor
Disease	N/A for non-human GPCRs
Length	478
Amino acid sequence	MXNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
UniProt	P08485
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL317
IUPHAR	16
DrugBank	N/A

Ligand

Name	CHEMBL127587
Molecular formula	C18H22INO3
IUPAC name	[(3R)-1-azabicyclo[2.2.2]octan-3-yl] (E,2R)-2-hydroxy-5-iodo-2-phenylpent-4-enoate
Molecular weight	427.282
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.2
Synonyms	(2R,4E)-2-Hydroxy-2-phenyl-5-iodo-4-pentenoic acid 1-azabicyclo[2.2.2]octan-3alpha-yl ester BDBM50031098 (E)-(R)-2-Hydroxy-5-iodo-2-phenyl-pent-4-enoic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester
Inchi Key	MMUQVFDMUDOFSH-UCPUOCAQSA-N
Inchi ID	InChI=1S/C18H22INO3/c19-10-4-9-18(22,15-5-2-1-3-6-15)17(21)23-16-13-20-11-7-14(16)8-12-20/h1-6,10,14,16,22H,7-9,11-13H2/b10-4+/t16-,18+/m0/s1
PubChem CID	10365181
ChEMBL	CHEMBL127587
IUPHAR	N/A
BindingDB	50031098
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	0.356 nM	PMID7562924	ChEMBL
Kd	0.356 nM	PMID7562924	BindingDB
Kd	2.39 nM	PMID7562924	ChEMBL
Kd	2.4 nM	PMID7562924	BindingDB

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