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Name | Muscarinic acetylcholine receptor M3 |
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Species | Homo sapiens (Human) |
Gene | CHRM3 |
Synonym | cholinergic receptor cholinergic receptor, muscarinic 3 cholinergic receptor, muscarinic 3, cardiac Chrm-3 HM4 [ Show all ] |
Disease | Urinary incontinence Overactive bladder Overactive bladder disorder Postoperative nausea and vomiting Respiratory disease [ Show all ] |
Length | 590 |
Amino acid sequence | MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL |
UniProt | P20309 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | T67684 |
ChEMBL | CHEMBL245 |
IUPHAR | 15 |
DrugBank | BE0000045 |
Name | CHEMBL62247 |
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Molecular formula | C24H26N2O4 |
IUPAC name | ethyl 17-ethoxy-6-methyl-12-oxa-1,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),5,9,14(19),15,17-heptaene-5-carboxylate |
Molecular weight | 406.482 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 4.2 |
Synonyms | 9-Ethoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-oxa-3,12a-diaza-benzo[a]cyclopenta[h]anthracene-1-carboxylic acid ethyl ester BDBM50071186 |
Inchi Key | BDIZCMDNZUBLMP-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C24H26N2O4/c1-4-28-16-6-7-17-15(12-16)10-11-26-13-18-20(30-23(17)26)9-8-19-22(18)21(14(3)25-19)24(27)29-5-2/h6-9,12,23,25H,4-5,10-11,13H2,1-3H3 |
PubChem CID | 44302775 |
ChEMBL | CHEMBL62247 |
IUPHAR | N/A |
BindingDB | 50071186 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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IC50 | 2629.0 nM | PMID9873472 | BindingDB,ChEMBL |
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