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GPCR

NameNociceptin receptor
SpeciesMus musculus (Mouse)
GeneOprl1
SynonymNOP receptor
NOP-r
NOPr
OP4
ORGC
[ Show all ]
DiseaseN/A for non-human GPCRs
Length367
Amino acid sequenceMESLFPAPFWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
UniProtP35377
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3621
IUPHAR320
DrugBankN/A

Ligand

NameCID 49850694
Molecular formulaC87H139N31O24
IUPAC name(2S,5S,8S,11S,19S)-N-[(2S)-1-[[(2S)-6-amino-1-[[(2S,5S,8S,11S,19S)-5-(2-amino-2-oxoethyl)-8-(3-amino-3-oxopropyl)-11-carbamoyl-2-methyl-3,6,9,13,20-pentaoxo-1,4,7,10,14-pentazacycloicos-19-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]-5-(4-aminobutyl)-19-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-2-(3-carbamimidamidopropyl)-8-(hydroxymethyl)-3,6,9,13,20-pentaoxo-1,4,7,10,14-pentazacycloicosane-11-carboxamide
Molecular weight2003.26
Hydrogen bond acceptor29
Hydrogen bond donor33
XlogP-10.9
SynonymsN/A
Inchi KeyMOGLXRZTMMGMRC-NJVGWAEZSA-N
Inchi IDInChI=1S/C87H139N31O24/c1-46-72(129)115-60(39-64(92)122)81(138)113-57(29-30-63(91)121)80(137)114-58(71(93)128)40-65(123)98-33-16-12-26-52(74(131)105-46)108-76(133)53(23-9-13-31-88)109-78(135)56(28-18-36-101-87(96)97)112-82(139)61-41-66(124)99-34-15-11-25-51(75(132)111-55(27-17-35-100-86(94)95)77(134)110-54(24-10-14-32-89)79(136)117-62(45-119)84(141)116-61)106-69(127)44-104-85(142)70(47(2)120)118-83(140)59(38-49-21-7-4-8-22-49)107-68(126)43-102-67(125)42-103-73(130)50(90)37-48-19-5-3-6-20-48/h3-8,19-22,46-47,50-62,70,119-120H,9-18,23-45,88-90H2,1-2H3,(H2,91,121)(H2,92,122)(H2,93,128)(H,98,123)(H,99,124)(H,102,125)(H,103,130)(H,104,142)(H,105,131)(H,106,127)(H,107,126)(H,108,133)(H,109,135)(H,110,134)(H,111,132)(H,112,139)(H,113,138)(H,114,137)(H,115,129)(H,116,141)(H,117,136)(H,118,140)(H4,94,95,100)(H4,96,97,101)/t46-,47+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,70-/m0/s1
PubChem CID49850694
ChEMBLCHEMBL1631923
IUPHARN/A
BindingDB50333095
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC500.6026 nMPMID21067234ChEMBL
EC500.61 nMPMID21067234BindingDB,ChEMBL
Emax94.0 %PMID21067234ChEMBL

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