You can:
Name | Nociceptin receptor |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Oprl1 |
Synonym | NOP receptor NOP-r NOPr OP4 Orphanin FQ receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 367 |
Amino acid sequence | MESLFPAPYWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASSLHREMQVSDRVRSIAKDVGLGCKTSETVPRPA |
UniProt | P35370 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4503 |
IUPHAR | 320 |
DrugBank | N/A |
Name | CHEMBL405645 |
---|---|
Molecular formula | C60H98N22O15 |
IUPAC name | (2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]pentanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide |
Molecular weight | 1367.58 |
Hydrogen bond acceptor | 20 |
Hydrogen bond donor | 22 |
XlogP | -7.3 |
Synonyms | N/A |
Inchi Key | MQWVPDARSJDVSG-RWDFPFHBSA-N |
Inchi ID | InChI=1S/C60H98N22O15/c1-33(74-46(86)31-73-58(97)48(35(3)84)82-56(95)43(28-37-17-8-5-9-18-37)76-47(87)30-71-45(85)29-72-52(91)38(63)27-36-15-6-4-7-16-36)50(89)78-42(22-14-26-70-60(67)68)54(93)80-40(20-12-24-62)55(94)81-44(32-83)57(96)75-34(2)51(90)79-41(21-13-25-69-59(65)66)53(92)77-39(49(64)88)19-10-11-23-61/h4-9,15-18,33-35,38-44,48,83-84H,10-14,19-32,61-63H2,1-3H3,(H2,64,88)(H,71,85)(H,72,91)(H,73,97)(H,74,86)(H,75,96)(H,76,87)(H,77,92)(H,78,89)(H,79,90)(H,80,93)(H,81,94)(H,82,95)(H4,65,66,69)(H4,67,68,70)/t33-,34-,35+,38-,39-,40-,41-,42-,43-,44-,48-/m0/s1 |
PubChem CID | 44414340 |
ChEMBL | CHEMBL405645 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 1.56 - | PMID16714110 | ChEMBL |
Activity | 2.45 - | PMID16714110 | ChEMBL |
EC50 | 213.8 nM | PMID16714110 | ChEMBL |
EC50 | 234.42 nM | PMID16714110 | ChEMBL |
Emax | -77.0 % | PMID16714110 | ChEMBL |
Emax | -71.0 % | PMID16714110 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218