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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	B2 bradykinin receptor
Species	Rattus norvegicus (Rat)
Gene	Bdkrb2
Synonym	B2 receptor B2BKR B2BRA BK-2 receptor BK2R bradykinin receptor B2R [ Show all ]
Disease	N/A for non-human GPCRs
Length	396
Amino acid sequence	MDTRSSLCPKTQAVVAVFWGPGCHLSTCIEMFNITTQALGSAHNGTFSEVNCPDTEWWSWLNAIQAPFLWVLFLLAALENIFVLSVFCLHKTNCTVAEIYLGNLAAADLILACGLPFWAITIANNFDWLFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWSCTLLLSSPMLVFRTMKDYREEGHNVTACVIVYPSRSWEVFTNMLLNLVGFLLPLSIITFCTVRIMQVLRNNEMKKFKEVQTEKKATVLVLAVLGLFVLCWFPFQISTFLDTLLRLGVLSGCWNERAVDIVTQISSYVAYSNSCLNPLVYVIVGKRFRKKSREVYQAICRKGGCMGESVQMENSMGTLRTSISVDRQIHKLQDWAGNKQ
UniProt	P25023
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2501
IUPHAR	42
DrugBank	N/A

Ligand

Name	CHEMBL542179
Molecular formula	C28H32Cl2N2O3
IUPAC name	2-[1-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]-2-phenylpropan-2-yl]oxyacetic acid;hydrochloride
Molecular weight	515.475
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	None
Synonyms	N/A
Inchi Key	MRCXWMQCOSXOHR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H31ClN2O3.ClH/c1-28(34-20-26(32)33,24-10-6-3-7-11-24)21-30-16-18-31(19-17-30)27(22-8-4-2-5-9-22)23-12-14-25(29)15-13-23;/h2-15,27H,16-21H2,1H3,(H,32,33);1H
PubChem CID	45261099
ChEMBL	CHEMBL542179
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	45.6 %	PMID10509924	ChEMBL

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