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Name | Glucagon-like peptide 1 receptor |
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Species | Homo sapiens (Human) |
Gene | GLP1R |
Synonym | GLP-1-R GLP-1 receptor glucagon-like peptide 1 receptor GLP-1R |
Disease | Non-insulin dependent diabetes Type 2 diabetes Type 1/2 diabetes Type 1 diabetes Obesity [ Show all ] |
Length | 463 |
Amino acid sequence | MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS |
UniProt | P43220 |
Protein Data Bank | 5vew, 5otv, 3c5t, 4zgm, 3iol, 5otu, 5vex, 5otw, 5otx, 3c59, 5nx2 |
GPCR-HGmod model | P43220 |
3D structure model | This structure is from PDB ID 5vew. |
BioLiP | BL0418500,BL0418501, BL0418494,BL0418495, BL0380967, BL0143732, BL0143731, BL0379513,BL0379514, BL0418496,BL0418497, BL0143795, BL0143794, BL0378791,BL0378792, BL0167480, BL0167479, BL0324355,BL0324356, BL0418498,BL0418499, BL0324354, BL0380966 |
Therapeutic Target Database | T36075 |
ChEMBL | CHEMBL1784 |
IUPHAR | 249 |
DrugBank | BE0000857 |
Name | MLS000390375 |
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Molecular formula | C17H18Cl2N4O3 |
IUPAC name | 2-(4,5-dichloro-6-oxopyridazin-1-yl)-N-[2-(2-ethylanilino)-2-oxoethyl]-N-methylacetamide |
Molecular weight | 397.256 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 2.4 |
Synonyms | SMR000255342 2-(4,5-dichloro-6-oxopyridazin-1-yl)-N-[2-(2-ethylanilino)-2-oxoethyl]-N-methylacetamide AC1M9L9R CHEMBL1374788 BDBM42061 [ Show all ] |
Inchi Key | MRFCCGDBEJIXFA-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C17H18Cl2N4O3/c1-3-11-6-4-5-7-13(11)21-14(24)9-22(2)15(25)10-23-17(26)16(19)12(18)8-20-23/h4-8H,3,9-10H2,1-2H3,(H,21,24) |
PubChem CID | 2585250 |
ChEMBL | CHEMBL1374788 |
IUPHAR | N/A |
BindingDB | 42061 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Potency | 6309.6 nM | PubChem BioAssay data set | ChEMBL |
Potency | 28183.8 nM | PubChem BioAssay data set | ChEMBL |
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