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GPCR

Name5-hydroxytryptamine receptor 1D
SpeciesSus scrofa (Pig)
GeneHTR1D
Synonym5-HT-1D
5-HT1D
Serotonin receptor 1D
DiseaseN/A for non-human GPCRs
Length291
Amino acid sequenceAMTDLLVSILVMPISIPYTITQTWSFGQLLCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAIVWAISICISIPPLFWRQARAHEEISDCLVNTSQISYTIYSTCGAFYIPSLLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNPSLHEGHSHSAGSPLFFNHVKIKLADSVLERKRISAARERKATKTLGIILGAFIICWLPFFVASLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKVV
UniProtP79400
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4105
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL64727
Molecular formulaC20H18Cl2N4S
IUPAC name8-[4-[(2,4-dichlorophenyl)methyl]piperazin-1-yl]-5-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),3,7,9,11-pentaene
Molecular weight417.352
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP5.9
SynonymsBDBM50407791
SCHEMBL7300287
Inchi KeyMRVXWRYYLBBDQJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H18Cl2N4S/c21-15-4-3-14(16(22)12-15)13-24-7-9-25(10-8-24)19-17-2-1-6-26(17)18-5-11-27-20(18)23-19/h1-6,11-12H,7-10,13H2
PubChem CID10598044
ChEMBLCHEMBL64727
IUPHARN/A
BindingDB50407791
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5025118.9 nMPMID8642566BindingDB,ChEMBL

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