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GPCR

NameVasoactive intestinal polypeptide receptor 2
SpeciesRattus norvegicus (Rat)
GeneVipr2
SynonymVIP-R-2
VIP and PACAP receptor 2
PVR3
Pituitary adenylate cyclase-activating polypeptide type III receptor
PACAP-R3
[ Show all ]
DiseaseN/A for non-human GPCRs
Length437
Amino acid sequenceMRASVVLTCYCWLLVRVSSIHPECRFHLEIQEEETKCAELLSSQMENHRACSGVWDNITCWRPADIGETVTVPCPKVFSNFYSRPGNISKNCTSDGWSETFPDFIDACGYNDPEDESKITFYILVKAIYTLGYSVSLMSLTTGSIIICLFRKLHCTRNYIHLNLFLSFMLRAISVLVKDSVLYSSSGTLRCHDQPGSWVGCKLSLVFFQYCIMANFYWLLVEGLYLHTLLVAILPPSRCFLAYLLIGWGIPSVCIGAWIATRLSLEDTGCWDTNDHSIPWWVIRMPILISIVVNFALFISIVRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAAFPIGISSTYQILFELCVGSFQGLVVAVLYCFLNSEVQCELKRRWRGLCLTQPGSRDYRLHSWSMSRNGSESALQIHRGSRTQSFLQSETSVI
UniProtP35000
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHAR372
DrugBankN/A

Ligand

NameVIP Ala10
Molecular formulaC141H234N44O41S
IUPAC name(3S)-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1,4-diamino-1,4-dioxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoic acid
Molecular weight3233.75
Hydrogen bond acceptor49
Hydrogen bond donor48
XlogP-16.2
SynonymsBDBM85870
Inchi KeyMRXBKCBYFMZCOJ-QUWDSXFMSA-N
Inchi IDInChI=1S/C141H234N44O41S/c1-19-71(12)109(137(224)176-92(53-68(6)7)127(214)169-89(112(150)199)57-102(147)192)183-134(221)100(64-187)180-130(217)96(59-104(149)194)174-128(215)91(52-67(4)5)171-129(216)93(55-78-38-40-80(190)41-39-78)172-121(208)83(34-24-27-46-143)163-119(206)84(35-25-28-47-144)167-135(222)107(69(8)9)181-113(200)72(13)159-117(204)88(44-50-227-18)166-123(210)87(42-43-101(146)191)165-118(205)82(33-23-26-45-142)162-120(207)85(36-29-48-156-140(151)152)164-126(213)90(51-66(2)3)170-122(209)86(37-30-49-157-141(153)154)168-138(225)110(75(16)188)184-115(202)74(15)160-124(211)95(58-103(148)193)173-131(218)98(61-106(197)198)178-139(226)111(76(17)189)185-132(219)94(54-77-31-21-20-22-32-77)177-136(223)108(70(10)11)182-114(201)73(14)161-125(212)97(60-105(195)196)175-133(220)99(63-186)179-116(203)81(145)56-79-62-155-65-158-79/h20-22,31-32,38-41,62,65-76,81-100,107-111,186-190H,19,23-30,33-37,42-61,63-64,142-145H2,1-18H3,(H2,146,191)(H2,147,192)(H2,148,193)(H2,149,194)(H2,150,199)(H,155,158)(H,159,204)(H,160,211)(H,161,212)(H,162,207)(H,163,206)(H,164,213)(H,165,205)(H,166,210)(H,167,222)(H,168,225)(H,169,214)(H,170,209)(H,171,216)(H,172,208)(H,173,218)(H,174,215)(H,175,220)(H,176,224)(H,177,223)(H,178,226)(H,179,203)(H,180,217)(H,181,200)(H,182,201)(H,183,221)(H,184,202)(H,185,219)(H,195,196)(H,197,198)(H4,151,152,156)(H4,153,154,157)/t71-,72-,73-,74-,75+,76+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,107-,108-,109-,110?,111-/m0/s1
PubChem CID91899013
ChEMBLN/A
IUPHARN/A
BindingDB85870
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki724.0 nMPMID12388623BindingDB
Ki2661.0 nMPMID12388623BindingDB

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