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Name | 5-hydroxytryptamine receptor 4 |
---|---|
Species | Homo sapiens (Human) |
Gene | HTR4 |
Synonym | 5-HT-4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5-HT4 receptor 5-HT4 serotonin receptor 4 |
Disease | N/A |
Length | 388 |
Amino acid sequence | MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT |
UniProt | Q13639 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q13639 |
3D structure model | This predicted structure model is from GPCR-EXP Q13639. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1875 |
IUPHAR | 9 |
DrugBank | BE0000084 |
Name | CHEMBL371718 |
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Molecular formula | C46H70Cl2N6O8 |
IUPAC name | 2-[4-[2-[[12-[2-[1-[2-(4-amino-5-chloro-2-methoxybenzoyl)oxyethyl]piperidin-4-yl]ethylamino]-12-oxododecanoyl]amino]ethyl]piperidin-1-yl]ethyl 4-amino-5-chloro-2-methoxybenzoate |
Molecular weight | 906.0 |
Hydrogen bond acceptor | 12 |
Hydrogen bond donor | 4 |
XlogP | 7.9 |
Synonyms | 1-[2-(4-amino-5-chloro-2-methoxyphenylcarbonyloxy)ethyl]-4-{2-[10-(2-{1-[2-(4-amino-5-chloro-2-methoxyphenylcarbonyloxy)ethyl]hexahydro-4-pyridinyl}ethylcarbamoyl)decylcarboxamido]ethyl}hexahydropyridine BDBM50174431 2-{4-[2-(11-{[2-(1-{2-[(4-amino-5-chloro-2-methoxyphenyl)carbonyloxy]ethyl}piperidin-4-yl)ethyl]carbamoyl}undecanamido)ethyl]piperidin-1-yl}ethyl 4-amino-5-chloro-2-methoxybenzoate |
Inchi Key | BEBWFSLBSVUCNK-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C46H70Cl2N6O8/c1-59-41-31-39(49)37(47)29-35(41)45(57)61-27-25-53-21-15-33(16-22-53)13-19-51-43(55)11-9-7-5-3-4-6-8-10-12-44(56)52-20-14-34-17-23-54(24-18-34)26-28-62-46(58)36-30-38(48)40(50)32-42(36)60-2/h29-34H,3-28,49-50H2,1-2H3,(H,51,55)(H,52,56) |
PubChem CID | 11714901 |
ChEMBL | CHEMBL371718 |
IUPHAR | N/A |
BindingDB | 50174431 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 6.0 % | PMID17676726 | ChEMBL |
Activity | 108.0 % | PMID17676726 | ChEMBL |
cAMP | 6.0 % | PMID16190749 | ChEMBL |
Ki | 9.0 nM | PMID17676726 | BindingDB,ChEMBL |
Ki | 18.0 nM | PMID16190749 | BindingDB,ChEMBL |
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