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GPCR

NameGlucose-dependent insulinotropic receptor
SpeciesHomo sapiens (Human)
GeneGPR119
SynonymGPCR2
GPR119
G-protein coupled receptor 2
G-protein coupled receptor 119
G protein-coupled receptor 119
[ Show all ]
DiseaseType 2 diabetes
Diabetes
Peripheral arterial disease; Type 2 diabetes
Non-insulin dependent diabetes
Gastric cancer; Type 2 diabetes
Length335
Amino acid sequenceMESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProtQ8TDV5
Protein Data BankN/A
GPCR-HGmod modelQ8TDV5
3D structure modelThis predicted structure model is from GPCR-EXP Q8TDV5.
BioLiPN/A
Therapeutic Target DatabaseT93788
ChEMBLCHEMBL5652
IUPHAR126
DrugBankN/A

Ligand

NameCHEMBL3113017
Molecular formulaC25H19ClF2N4O4S
IUPAC name5-[2-chloro-6-[[1-(3,4-difluorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Molecular weight544.958
Hydrogen bond acceptor10
Hydrogen bond donor0
XlogP5.4
SynonymsBDBM50447729
Inchi KeyBEGZMYMDNPFYOC-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H19ClF2N4O4S/c26-22-10-16(25-30-24(31-36-25)15-3-4-15)11-23(29-22)35-17-6-5-14-2-1-9-32(21(14)12-17)37(33,34)18-7-8-19(27)20(28)13-18/h5-8,10-13,15H,1-4,9H2
PubChem CID76314048
ChEMBLCHEMBL3113017
IUPHARN/A
BindingDB50447729
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC5090.0 nMPMID24440299BindingDB,ChEMBL
Efficacy100.0 %PMID24440299ChEMBL

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