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GPCR

NameNeuropeptide Y receptor type 1
SpeciesHomo sapiens (Human)
GeneNPY1R
Synonymneuropeptide Y receptor type 1
NPY-Y1 receptor
NPY1-R
FC5
Y1 receptor
[ Show all ]
DiseaseHypertension; Obesity; Heart disease
Obesity
Eating disorders reduction in food intake obesity anxiety
Eating disorders reduction in food intake
Eating disorder
[ Show all ]
Length384
Amino acid sequenceMNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
UniProtP25929
Protein Data Bank5zbh
GPCR-HGmod modelP25929
3D structure modelThis structure is from PDB ID 5zbh.
BioLiPBL0411971
Therapeutic Target DatabaseT89213
ChEMBLCHEMBL4777
IUPHAR305
DrugBankN/A

Ligand

NameCID 44346875
Molecular formulaC104H168N34O27
IUPAC name(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3S)-2-[[(3R,6S,9S,14S,17S,20R,23S,26R,29S)-3-(4-aminobutyl)-9-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-20-[3-(diaminomethylideneamino)propyl]-6-(hydroxymethyl)-17-(1H-imidazol-4-ylmethyl)-14,26-dimethyl-23-(2-methylpropyl)-2,5,8,12,16,19,22,25,28-nonaoxo-1,4,7,13,15,18,21,24,27-nonazabicyclo[27.3.0]dotriacontane-14-carbonyl]amino]-3-methylpentanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid
Molecular weight2326.7
Hydrogen bond acceptor33
Hydrogen bond donor34
XlogP-8.4
SynonymsN/A
Inchi KeyBEKFUXZUYPEWOZ-PFSTWLEPSA-N
Inchi IDInChI=1S/C104H168N34O27/c1-12-53(7)79(96(160)134-81(56(10)140)97(161)125-65(23-18-40-118-103(113)114)84(148)124-66(33-35-76(107)143)87(151)122-64(22-17-39-117-102(111)112)86(150)131-73(99(163)164)45-58-27-31-61(142)32-28-58)133-91(155)70(43-52(5)6)128-90(154)72(47-77(108)144)130-95(159)80(54(8)13-2)135-100(165)104(11)136-78(145)36-34-67(121-83(147)62(106)44-57-25-29-60(141)30-26-57)88(152)132-74(49-139)92(156)126-68(20-14-15-37-105)98(162)138-41-19-24-75(138)94(158)120-55(9)82(146)127-69(42-51(3)4)89(153)123-63(21-16-38-116-101(109)110)85(149)129-71(93(157)137-104)46-59-48-115-50-119-59/h25-32,48,50-56,62-75,79-81,139-142H,12-24,33-47,49,105-106H2,1-11H3,(H2,107,143)(H2,108,144)(H,115,119)(H,120,158)(H,121,147)(H,122,151)(H,123,153)(H,124,148)(H,125,161)(H,126,156)(H,127,146)(H,128,154)(H,129,149)(H,130,159)(H,131,150)(H,132,152)(H,133,155)(H,134,160)(H,135,165)(H,136,145)(H,137,157)(H,163,164)(H4,109,110,116)(H4,111,112,117)(H4,113,114,118)/t53-,54-,55+,56+,62-,63+,64-,65-,66-,67-,68+,69-,70-,71-,72-,73-,74-,75-,79-,80-,81-,104-/m0/s1
PubChem CID44346875
ChEMBLCHEMBL385339
IUPHARN/A
BindingDB50003051
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Kd<1000.0 nMPMID1433176BindingDB,ChEMBL

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