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GPCR

Name5-hydroxytryptamine receptor 2C
SpeciesRattus norvegicus (Rat)
GeneHtr2c
Synonym5-HT-1C
serotonin 1c receptor
HTR1C
5-hydroxytryptamine receptor 1C
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
[ Show all ]
DiseaseN/A for non-human GPCRs
Length460
Amino acid sequenceMVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
UniProtP08909
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL324
IUPHAR8
DrugBankBE0004882

Ligand

NameCHEMBL310940
Molecular formulaC22H27N3O
IUPAC name4-[(4-methylpiperazin-1-yl)methyl]-3-oxa-2-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7,9,11,14,16-hexaene
Molecular weight349.478
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP3.7
Synonyms2-(4-Methylpiperazinomethyl)-2,3,3a,8-tetrahydro-1-oxa-12b-azadibenzo[e,h]azulene
BDBM50403968
Inchi KeyBELFTABQPVPWDW-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H27N3O/c1-23-10-12-24(13-11-23)16-19-15-22-20-8-4-2-6-17(20)14-18-7-3-5-9-21(18)25(22)26-19/h2-9,19,22H,10-16H2,1H3
PubChem CID44461656
ChEMBLCHEMBL310940
IUPHARN/A
BindingDB50403968
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ED50<2.5 mg.kg-1PMID11755364ChEMBL

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